Catheter-Related Bloodstream Infections in the Intensive Care Unit Population

Catheter-related bloodstream infections (CRBIs) are a cause of significant morbidity and mortality in intensive care unit patients. Development of CRBIs may occur by several mechanisms. The role of fibrin and biofilm development and their impact on therapy are described. Multiple preventative strategies related to the insertion and maintenance of the catheter site have been identified. Topical antisepsis and use of antibiotic-impregnated catheters are also beneficial for reducing the incidence of CRBI. Antibiotic lock solutions may be effective in preventing CRBI for select patients with long-term catheter use. Treatment of CRBIs should be based on suspected organisms, which most commonly include staphylococci, gram-negatives, including Pseudomonas aeruginosa and Candida species. Duration of treatment and decisions regarding catheter removal are controversial. Evaluation and treatment of potential complications of CRBIs, including endocarditis, infected thrombophlebitis, osteomyelitis, and endophthalmitis, are essential.