A-63162, A POTENT ORALLY ACTIVE INHIBITOR OF 5-LIPOXYGENASE (5-LO)

被引：0
|
作者：
CARTER, GW [1 ]
YOUNG, PR [1 ]
DYER, R [1 ]
ALBERT, DH [1 ]
BOUSKA, J [1 ]
BARLOW, J [1 ]
ROBERTS, E [1 ]
SONSALLA, J [1 ]
SUMMERS, J [1 ]
BROOKS, D [1 ]
机构：
[1] ABBOTT LABS, N CHICAGO, IL 60064 USA
来源：
FASEB JOURNAL | 1988年 / 2卷 / 05期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：A1263 / A1263
页数：1
相关论文
共 50 条
  • [21] A DOUBLE-BLIND MULTICENTER STUDY OF ZILEUTON, A POTENT 5-LIPOXYGENASE (5-LO) INHIBITOR VERSUS PLACEBO IN THE TREATMENT OF SPONTANEOUS ASTHMA IN ADULTS
    ISRAEL, E
    DRAZEN, J
    PEARLMAN, H
    COHN, J
    RUBIN, P
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 89 (01) : 236 - 236
  • [22] INHIBITION OF EQUINE MONONUCLEAR CELL-PROLIFERATION AND LEUKOTRIENE B4 SYNTHESIS BY A SPECIFIC 5-LIPOXYGENASE INHIBITOR, A-63162
    OLSEN, SC
    ATLURU, D
    ATLURU, S
    MCVEY, DS
    AMERICAN JOURNAL OF VETERINARY RESEARCH, 1992, 53 (06) : 1015 - 1018
  • [23] Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12
    Ball, Ann-Katrin
    Beilstein, Kim
    Wittmann, Sandra
    Sueruen, Duran
    Saul, Meike J.
    Schnuetgen, Frank
    Flamand, Nicolas
    Capelo, Ricardo
    Kahnt, Astrid S.
    Frey, Helena
    Schaefer, Liliana
    Marschalek, Rolf
    Haefner, Ann-Kathrin
    Steinhilber, Dieter
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2017, 1862 (05): : 561 - 571
  • [24] Possible role of 5-lipoxygenase (5-LO) pathway in eosinophils chemotaxis to acetylsalicylic acid
    Kurowski, M
    Kuprys, I
    Kuzminska, B
    Gorski, P
    Kuna, P
    ALLERGY, 2002, 57 : 134 - 134
  • [25] EXVIVO SYNTHESIS OF 5-LIPOXYGENASE (5-LO) PRODUCTS BY RAT PLEURISY EXUDATE CELLS
    CASEY, FB
    LANNI, C
    DILLON, KM
    CRAWFORD, AC
    FEDERATION PROCEEDINGS, 1985, 44 (04) : 984 - 984
  • [26] Interdependent roles of nitric oxide (NO) and 5-lipoxygenase (5-LO) during accelerated nephrotoxic serum nephritis (aNTS) in 5-LO gene deleted mice (5-LO-/-).
    Munger, KA
    Cruet, E
    Fogo, A
    Funk, C
    Badr, KF
    FASEB JOURNAL, 1996, 10 (03): : 2165 - 2165
  • [27] Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO): Studies in rats and 5-LO knockout mice
    Beierschmitt, WP
    McNeish, JD
    Griffiths, RJ
    Nagahisa, A
    Nakane, M
    Amacher, DE
    TOXICOLOGICAL SCIENCES, 2001, 63 (01) : 15 - 21
  • [28] STRUCTURE-ACTIVITY-RELATIONSHIPS LEADING TO WY-47,288, A TOPICALLY-ACTIVE INHIBITOR OF 5-LIPOXYGENASE (5-LO) TRANSLOCATION
    KREFT, A
    BICKSLER, J
    PATTISON, T
    BANKER, A
    MUSSER, J
    KEES, K
    YARDLEY, J
    HOLLOWAY, D
    STURM, R
    CHANG, J
    CARLSON, RP
    WONG, A
    HWANG, SM
    MARSHALL, L
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 206 : 40 - MEDI
  • [29] Interleukin-5 enhances expression of 5-lipoxygenase activating protein (FLAP), but not of 5-lipoxygenase (5-LO), in human blood eosinophils.
    Cowburn, AS
    Seymour, ML
    Holgate, ST
    Sampson, AP
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 101 (01) : S230 - S231
  • [30] BENZOXEPIN AND BENZOTHIEPIN DERIVATIVES AS POTENT, ORALLY-ACTIVE INHIBITORS OF 5-LIPOXYGENASE
    SATOH, Y
    LIBBY, AH
    POWERS, C
    KOWALSKI, TJ
    WHITE, DH
    KIMBLE, EF
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (04) : 549 - 552
12345