SELF-STERILIZING POLYMERS - CONTROLLED RELEASE OF GLUTARALDEHYDE

被引:2
|
作者
GREENWALD, RB
SZE, ISY
MCSHERRY, D
机构
[1] Ecolab Research Center Ecolab, Inc., St. Paul
关键词
D O I
10.1177/088391159200700108
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
alpha,beta-unsaturated derivatives of 2-methoxy-2H-3,4-dihydropyran were synthesized. Stereochemical considerations of these heterocycles are briefly discussed. These compounds undergo a rapid first order reaction with water to produce glutaraldehyde, a potent microbial sterilant. Copolymers derived from these compounds and HEMA were found to provide excellent examples of clear, hard-sanitizing films; presumably by reaction with atmospheric moisture. Microbiological assays indicate that the release rates of the active agent from the polymers vary greatly depending on the hydrophilicity of the comonomers.
引用
收藏
页码:82 / 99
页数:18
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