CYCLIC CHANGES IN VEGETATIVE REGULATION OF HEMODYNAMICS AND CLONIDINE EFFECTS IN WOMEN WITH ESSENTIAL-HYPERTENSION

As many as 56 healthy women and 45 women of reproductive age, suffering from essential hypertension (EH) were examined for the effect of ovarian cycle phases on vegetative regulation of central hemodynamics and pharmacodynamic effects of hemiton. The healthy persons in the phase of proliferation (I) and secretion (III) demonstrated the predominance of the parasympathetic tone and high responsivenes of the autonomic nervous system (ANS). The phase of ovulation (II) and the menstrual phase (IV) were characterized by the high sympathetic tone and low responsiveness of both parts of the ANS. The lowest values of the stroke and minute blood volumes were detected in phase II, whereas the highest ones in phase IV. In EH patients, the recurrence of ANS function was disturbed, the dynamics of the parameters became opposite to that seen in healthy persons. Hemiton produced the maximal hypotensive effect in phases I and II, the minimal one in phases III and IV. In phases I and III, the drug minimized the cardiac output; the general peripheral resistance was reduced in phases I and II; in phase IV, the drug did not provoke any significant changes in hemodynamics. The data obtained permit a differentiated approach to the distribution of the hemiton dose required for the treatment course in EH women of reproductive age.