ENDOTHELIUM-DEPENDENT RELAXATION INDUCED BY SODIUM-FLUORIDE IN THE RABBIT EAR ARTERY

被引：1
|
作者：
TSURU, H
机构：
[1] Department of Pharmacology, Hiroshima University School of Medicine, Hiroshima, 734, Kasumi, Minami-ku
来源：
EXPERIENTIA | 1991年 / 47卷 / 07期
关键词：
SODIUM FLUORIDE; ENDOTHELIUM-DEPENDENT VASORELAXATION; RABBIT EAR ARTERY;
D O I：
10.1007/BF01958820
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sodium fluoride (NaF) produced concentration-dependent relaxation of isolated rabbit ear artery precontracted with norepinephrine. In contrast, an arterial preparation with the endothelium rubbed off did not relax, but contracted in response to NaF. NaF-induced relaxation was not influenced by indomethacin but was inhibited by methylene blue or N(G)-monomethyl-L-arginine. The results indicate that NaF relaxes the artery by releasing a so-called EDRF.
引用
收藏
页码：703 / 705
页数：3
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