EFFECT OF VINPOCETINE ON NORADRENERGIC NEURONS IN RAT LOCUS-CERULEUS

被引：9
|
作者：
GAAL, L
MOLNAR, P
机构：
[1] Department of Biochemistry, Pharmacological Research Centre, Chemical Works of Gedeon Richter Ltd., Budapest
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 187卷 / 03期
关键词：
Cognitive-enhancing effects; Locus coeruleus; Noradrenaline; Unit activity; Vinpocetine;
D O I：
10.1016/0014-2999(90)90383-H
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Conventional extracellular single unit recordings were used to investigate the effect of vinpocetine on locus coeruleus noradrenergic neurons in chloral hydrate-anesthetized rats. Vinpocetine produced a significant and dose-dependent increase in the firing rate of locus coeruleus neurons (ED30 = 075 mg/kg i.v.) up to 1 mg/kg i.v., followed by a complete blockade of spiking activity at doses higher than this. The effective dose range was in very good agreement with the dose range corresponding to the memory-enhancing effects of the compound. Our results supplied direct electrophysiological evidence that vinpocetine increases the activity of ascending noradrenergic pathways. This effect can be related to the cognitive-enhancing characteristics of the compound. © 1990.
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页码：537 / 539
页数：3
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