EFFECT OF VINPOCETINE ON NORADRENERGIC NEURONS IN RAT LOCUS-CERULEUS

被引：9
|
作者：
GAAL, L
MOLNAR, P
机构：
[1] Department of Biochemistry, Pharmacological Research Centre, Chemical Works of Gedeon Richter Ltd., Budapest
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 187卷 / 03期
关键词：
Cognitive-enhancing effects; Locus coeruleus; Noradrenaline; Unit activity; Vinpocetine;
D O I：
10.1016/0014-2999(90)90383-H
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Conventional extracellular single unit recordings were used to investigate the effect of vinpocetine on locus coeruleus noradrenergic neurons in chloral hydrate-anesthetized rats. Vinpocetine produced a significant and dose-dependent increase in the firing rate of locus coeruleus neurons (ED30 = 075 mg/kg i.v.) up to 1 mg/kg i.v., followed by a complete blockade of spiking activity at doses higher than this. The effective dose range was in very good agreement with the dose range corresponding to the memory-enhancing effects of the compound. Our results supplied direct electrophysiological evidence that vinpocetine increases the activity of ascending noradrenergic pathways. This effect can be related to the cognitive-enhancing characteristics of the compound. © 1990.
引用
收藏
页码：537 / 539
页数：3
相关论文
共 50 条
  • [1] ELECTROPHYSIOLOGICAL ACTIONS OF COCAINE ON NORADRENERGIC NEURONS IN RAT LOCUS-CERULEUS
    PITTS, DK
    MARWAH, J
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1987, 240 (01): : 345 - 351
  • [2] RELATIONSHIP OF NORADRENERGIC LOCUS-CERULEUS NEURONS TO CERVICOSPINAL REFLEXES
    POMPEIANO, O
    POSTURE AND GAIT : DEVELOPMENT, ADAPTATION AND MODULATION, 1988, 812 : 355 - 367
  • [3] ACTIVITY OF CAT LOCUS-CERULEUS NORADRENERGIC NEURONS DURING THE DEFENSE REACTION
    LEVINE, ES
    LITTO, WJ
    JACOBS, BL
    BRAIN RESEARCH, 1990, 531 (1-2) : 189 - 195
  • [4] ELECTROPHYSIOLOGICAL EFFECTS OF DERMORPHIN ON LOCUS-CERULEUS NEURONS OF RAT
    CHIU, TH
    CHEN, TY
    HO, CL
    CHIANG, ST
    NEUROPHARMACOLOGY, 1990, 29 (08) : 747 - 755
  • [5] PHENOTYPIC PLASTICITY OF LOCUS-CERULEUS NORADRENERGIC NEURONS AFTER TRANSPLANTATION INTO THE DOPAMINE-DEPLETED CAUDATE IN THE RAT
    NISHINO, H
    HASHITANI, T
    KUMAZAKI, M
    ISHIDA, Y
    HIDA, H
    MAKINO, T
    SAKURAI, T
    FURUYAMA, F
    ISOBE, Y
    SATO, H
    PROGRESS IN BRAIN RESEARCH, 1990, 82 : 515 - 521
  • [6] CHEMOCYTOARCHITECTURE OF THE RAT LOCUS-CERULEUS
    IIJIMA, K
    HISTOLOGY AND HISTOPATHOLOGY, 1993, 8 (03) : 581 - 591
  • [7] PIGMENTED NEURONS IN LOCUS-CERULEUS OF ALCOHOLICS
    ARANGO, V
    UNDERWOOD, MD
    MANN, JJ
    LANCET, 1993, 342 (8868): : 445 - 446
  • [8] OPIOID-GLUTAMATE INTERACTIONS IN RAT LOCUS-CERULEUS NEURONS
    OLESKEVICH, S
    CLEMENTS, JD
    WILLIAMS, JT
    JOURNAL OF NEUROPHYSIOLOGY, 1993, 70 (03) : 931 - 937
  • [9] DEPOLARIZATION OF RAT LOCUS-CERULEUS NEURONS BY ADENOSINE 5'-TRIPHOSPHATE
    HARMS, L
    FINTA, EP
    TSCHOPL, M
    ILLES, P
    NEUROSCIENCE, 1992, 48 (04) : 941 - 952
  • [10] ACUTE MORPHINE INDUCES OSCILLATORY DISCHARGE OF NORADRENERGIC LOCUS-CERULEUS NEURONS IN THE WAKING MONKEY
    ASTONJONES, G
    RAJKOWSKI, J
    KUBIAK, P
    AKAOKA, H
    NEUROSCIENCE LETTERS, 1992, 140 (02) : 219 - 224
12345