LOCALIZATION OF THE RHODOPSIN GENE TO THE DISTAL HALF OF MOUSE CHROMOSOME-6

被引：24
|
作者：
ELLIOTT, RW
SPARKES, RS
MOHANDAS, T
GRANT, SG
MCGINNIS, JF
机构：
[1] MENTAL RETARDAT RES CTR,LOS ANGELES,CA 90024
[2] BRAIN RES INST,DEPT MED,LOS ANGELES,CA 90024
[3] BRAIN RES INST,DEPT ANAT,LOS ANGELES,CA 90024
[4] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT PEDIAT,TORRANCE,CA 90509
来源：
GENOMICS | 1990年 / 6卷 / 04期
关键词：
D O I：
10.1016/0888-7543(90)90498-J
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We have assigned the mouse rhodopsin gene, Rho, to chromosome 6 using DNA from a set of mousehamster somatic hybrid cell lines and a partial cDNA clone for mouse opsin. This assignment rules out the direct involvement of the rhodopsin gene in the known mouse mutations that produce retinal degeneration, including retinal degeneration slow (rds, chromosome 17), retinal degeneration (rd, chromosome 5), Purkinje cell degeneration (pcd, chromosome 13), and nervous (nr, chromosome 8). Segregation of Rho-specific DNA fragment differences among 50 animals from an interspecific backcross (C57BL/6J × Mus spretus) × C57BL/6J indicates that the Rho locus is 4.0 ± 2.8 map units distal to the locus for the proto-oncogene Raf-1 and 18.0 ± 5.4 map units proximal to the locus for the proto-oncogene Kras-2. Linkage to Raf-1 was confirmed using four sets of recombinant inbred strains. The two loci RAF1 and RHO are also syntenic on human chromosome 3, but on opposite arms. © 1990.
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页码：635 / 644
页数：10
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