LIPID A MUTANTS OF VIBRIO-CHOLERAE - ISOLATION AND PARTIAL CHARACTERIZATION

被引：5
|
作者：
PAUL, S
SEN, AK
BANERJEE, N
CHATTERJEE, AN
DAS, J
机构：
[1] INDIAN INST CHEM BIOL,DIV BIOPHYS,CALCUTTA 700032,W BENGAL,INDIA
[2] INDIAN INST CHEM BIOL,DEPT ORGAN CHEM,CALCUTTA 700032,W BENGAL,INDIA
[3] JADAVPUR UNIV,DEPT FOOD TECH & BIOCHEM ENGN,CALCUTTA 700032,W BENGAL,INDIA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 01期
关键词：
D O I：
10.1016/0006-291X(90)91441-T
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vibriocholerae mutants resistant to common antibiotics and neutral and anionic detergents were isolated. Analysis of isolated outer membranes revealed a significant deficiency in the acylation of lipid A in the resistant strains. The content of amide-linked and ester-bound fatty acids in the lipid A of the mutant strains compared to that of the wild type was about 50-56% and 29-37% respectively. This defect was specific for lipid A as there was no change in the acylation of phospholipids. The reduction in fatty acid content of lipid A was reflected in the altered endotoxic properties in the mutant strains. © 1990.
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页码：116 / 122
页数：7
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