SYNTHETIC CEPHALOSPORINS .7. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7-[(Z)-2-(2-AMINOTHIAZOL-4-YL)-2-(3-(3-HYDROXY-4-PYRIDON-1-YL)-3-CARBOXYPROPOXYIMINO)ACETAMIDO]-3-(1,2,3-THIADIAZOL-5-YL)-THIOMETHYL-3-CEPHEM-4-CARBOXYLIC ACID AND ITS RELATED-COMPOUNDS

被引：20

作者：

SAKAGAMI, K ^{[1
]}

IWAMATSU, K ^{[1
]}

ATSUMI, K ^{[1
]}

HATANAKA, M ^{[1
]}

机构：

[1] OSAKA UNIV, INST SCI & IND RES, IBARAKI, OSAKA 567, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 12期

关键词：

CEPHALOSPORINS; ANTI-PSEUDOMONAL ACTIVITY; STRUCTURE ACTIVITY RELATIONSHIPS; 3-HYDROXY-4-PYRIDONE;

D O I：

10.1248/cpb.38.3476

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and antibacterial activity of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(3-(3-hydroxy-4-pyridon-1-yl)-3-carboxypropoxyimino)acetamido]-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid and (12a) and its related compounds are described. Compound 12a exhibited excellent antibacterial activity against gram-negative bacteria, including Pseudomonas aeruginosa.

引用

页码：3476 / 3479

页数：4

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