ULTRAVIOLET-B IRRADIATION INCREASES ENDOTHELIN-1 AND ENDOTHELIN RECEPTOR EXPRESSION IN CULTURED HUMAN KERATINOCYTES

被引：35
|
作者：
TSUBOI, R [1 ]
SATO, C [1 ]
OSHITA, Y [1 ]
HAMA, H [1 ]
SAKURAI, T [1 ]
GOTO, K [1 ]
OGAWA, H [1 ]
机构：
[1] UNIV TSUKUBA,INST BASIC MED SCI,DEPT PHARMACOL,TSUKUBA,IBARAKI 305,JAPAN
来源：
FEBS LETTERS | 1995年 / 371卷 / 02期
关键词：
ENDOTHELIN-1; ENDOTHELIN RECEPTOR; ULTRAVIOLET B; KERATINOCYTE;
D O I：
10.1016/0014-5793(95)00912-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of ultraviolet B (UVB) irradiation on endothelin-l (ET-1) and ET receptor expression was examined using cultured normal human keratinocytes. Keratinocytes secreted ET-1 in the medium at a level of 2.1 pg/day/10(5) cells. UVB irradiation up to 10 mJ/cm(2) increased ET-I secretion 3-fold, and potentiated expression of mRNA for ET-1. Both ET(A) and ET(B) receptor mRNAs were detected in keratinocytes, and their expression was up-regulated by 5 mJ/cm(2) UVB irradiation.
引用
收藏
页码：188 / 190
页数：3
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