VANADIUM AND OXYGEN FREE-RADICALS - INHIBITION OF SUPEROXIDE-DISMUTASE AND ENHANCEMENT OF HYDROXYDOPAMINE OXIDATION

被引：0
|
作者：
SHAINKINKESTENBAUM, R
CARUSO, C
BERLYNE, GM
机构：
[1] VET ADM MED CTR,111F,800 POLY PL,BROOKLYN,NY 11209
[2] VET ADM MED CTR,NEPHROL SECT,BROOKLYN,NY 11209
来源：
TRACE ELEMENTS IN MEDICINE | 1991年 / 8卷 / 01期
关键词：
VANADIUM; OXYGEN FREE RADICALS; SUPEROXIDE DISMUTASE; CATECHOLAMINES;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1) The effect of vanadium on superoxide dismutase activity (SOD), as well as on the rate of hydroxydopamine oxidation was studied in vitro since lipid peroxidation has been implicated in cell damage by vanadium. 2) Vanadium strongly inhibits SOD activity, the degree of inhibition increasing with time. 3) Vanadium enhances the rate of hydroxydopamine autoxidation. Maximal oxidation in the presence of 1-mu-g/ml vanadium was 3 minutes in comparison to 8 minutes in control system. 4) The combination of excessive oxygen free radical production and inhibition of their elimination by inhibition of SOD activity, may contribute to vanadium toxicity and carcinogenicity, in which lipid peroxidation has been already implicated as the mechanism of cell damage.
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页码：6 / 10
页数：5
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