HLA-A29.2 SUBTYPE ASSOCIATED WITH BIRDSHOT RETINOCHOROIDOPATHY

被引：75
|
作者：
LEHOANG, P
OZDEMIR, N
BENHAMOU, A
TABARY, T
EDELSON, C
BETUEL, H
SEMIGLIA, R
COHEN, JHM
机构：
[1] CENT REG TRANSFUS SANGUINE,LYONS,FRANCE
[2] CROIX ROUSSE HOSP,DEPT OPHTHALMOL,LYONS,FRANCE
[3] UNIV REIMS,ROBERT DEBRE HOSP,DEPT IMMUNOL,INSERM,F-51100 REIMS,FRANCE
来源：
AMERICAN JOURNAL OF OPHTHALMOLOGY | 1992年 / 113卷 / 01期
关键词：
D O I：
10.1016/S0002-9394(14)75749-6
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Birdshot retinochoroidopathy is strongly associated with HLA-A29. This antigen can be divided into two subtypes, A29.1 and A29.2, using an immunoprecipitation method succeeded by one-dimensional electrofocusing gel electrophoresis. We reviewed the HLA typings of 58 white French patients who had birdshot retinochoroidopathy. Of these 58 subjects, 54 (93.1%) had HLA-A29 with a relative risk of 157.30. We further analyzed the HLA-A29 subtypings of 33 patients with birdshot retinochoroidopathy. Evaluation of the results showed that HLA-A29.2 subtype was present in all patients (100%). We concluded that the absence of HLA-A29.1 subtype is statistically significant (P < .01) in this study of HLA-A29 subtyping.
引用
收藏
页码：33 / 35
页数：3
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