INHIBITION OF DNA TOPOISOMERASE-I ACTIVITY BY DIETHYLSTILBESTROL AND ITS ANALOGS

被引：0
|
作者：
ODA, T
SATO, Y
KODAMA, M
KANEKO, M
机构：
[1] KYORITSU COLL PHARMACEUT SCI, SHIBAKOEN 1 CHOME, MINATO KU, TOKYO 105, JAPAN
[2] NATL CANC CTR, RES INST, DIV BIOPHYS, CHUO KU, TOKYO 104, JAPAN
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1993年 / 16卷 / 07期
关键词：
DIETHYLSTILBESTROL; INDENESTROL; DNA TOPOISOMERASE; DIENESTROL; CHINESE HAMSTER V79 CELL;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Diethylstilbestrol and its derivatives were tested to determine their inhibitory effects on the relaxation activity of DNA topoisomerase I using cell lysates from Chinese hamster V79 cells. Among the derivatives investigated, (+/-)-indenestrol B, (+/-)-IB, showed the strongest inhibitory effect.
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页码：708 / 710
页数：3
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