EXPRESSION CLONING OF AN EPITHELIAL AMILORIDE-SENSITIVE NA+ CHANNEL - A NEW CHANNEL TYPE WITH HOMOLOGIES TO CAENORHABDITIS-ELEGANS DEGENERINS

被引：327
|
作者：
LINGUEGLIA, E [1 ]
VOILLEY, N [1 ]
WALDMANN, R [1 ]
LAZDUNSKI, M [1 ]
BARBRY, P [1 ]
机构：
[1] INST PHARMACOL MOLEC & CELLULAIRE,660 ROUTE LUCIOLES,F-06560 VALBONNE,FRANCE
来源：
FEBS LETTERS | 1993年 / 318卷 / 01期
关键词：
SODIUM CHANNEL; AMILORIDE; EPITHELIA; COLON; NEURONAL DEGENERATION; CAENORHABDITIS-ELEGANS;
D O I：
10.1016/0014-5793(93)81336-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A complementary DNA encoding an amiloride-sensitive Na+ channel has been cloned and characterized from rat colon. The protein encoded by the cDNA has a sequence of 699 amino acids (79 kDa) containing several putative membrane spanning domains and potential phosphorylation sites. It forms a channel that has the electrophysiological and pharmacological properties characteristic of the epithelial Na+ channel. Homologies (including in transmembrane domains) have been found between a part of the channel sequence and the Mec4 gene product of Caenorhabditis elegans, a protein associated with mutation-induced neuronal degeneration.
引用
收藏
页码：95 / 99
页数：5
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