T-CELL-MEDIATED CYTOTOXICITY

被引：15
|
作者：
BERKE, G
机构：
[1] The Weizmann Institute of Science, Rehovot
来源：
CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 03期
关键词：
D O I：
10.1016/0952-7915(91)90031-U
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
There are two competing theories to explain the mechanism(s) by which cytolytic T lymphocytes kill target cells: granule exocytosis of a pore-forming protein, and contact-induced internal disintegration. Accumulated evidence supports alternative pathways in lymphocytoxicity, possibly reflecting distinct effector functions expressed by different killer cells and cells at different stages of activation.
引用
收藏
页码：320 / 325
页数：6
相关论文
共 50 条
  • [31] THE MECHANISM OF T-CELL-MEDIATED LYSIS
    HENNEY, CS
    IMMUNOLOGY TODAY, 1980, 1 (02): : 36 - 41
  • [32] T-cell-mediated control of autoimmunity
    Don Mason
    Arthritis Research & Therapy, 3
  • [33] T-cell-mediated control of autoimmunity
    Mason, D
    ARTHRITIS RESEARCH, 2001, 3 (03) : 133 - 135
  • [34] Aging and T-cell-mediated immunity
    Chakravarti, B
    Abraham, GN
    MECHANISMS OF AGEING AND DEVELOPMENT, 1999, 108 (03) : 183 - 206
  • [35] FAS ANTIGEN IS THE MAJOR TARGET MOLECULE FOR CD4+ T-CELL-MEDIATED CYTOTOXICITY
    STALDER, T
    HAHN, SH
    ERB, P
    JOURNAL OF IMMUNOLOGY, 1994, 152 (03): : 1127 - 1133
  • [36] T-CELL-MEDIATED CYTOTOXICITY - DISCRIMINATION BETWEEN ANTIGEN RECOGNITION, LETHAL HIT AND CYTOLYSIS PHASE
    WAGNER, H
    ROLLINGHOFF, M
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1974, 4 (11) : 745 - 750
  • [37] 17TH FORUM IN IMMUNOLOGY - MOLECULAR MECHANISM OF T-CELL-MEDIATED CYTOTOXICITY - DISCUSSION
    GOLSTEIN, P
    NABHOLZ, M
    TSCHOPP, J
    PODACK, ER
    LOWREY, DM
    BERKE, G
    RUDDLE, NH
    HENKART, P
    ANNALES DE L INSTITUT PASTEUR-IMMUNOLOGY, 1987, 138 (02): : 336 - 342
  • [38] T-CELL-MEDIATED CYTOTOXICITY OF HUMAN GLIOMAS - A TUMOR NECROSIS FACTOR-INDEPENDENT MECHANISM
    BALTUCH, GH
    VILLEMURE, LG
    MCCREA, E
    ANTEL, JP
    NEUROSURGERY, 1994, 35 (03) : 450 - 456
  • [39] 17TH FORUM IN IMMUNOLOGY - MOLECULAR MECHANISM OF T-CELL-MEDIATED CYTOTOXICITY - INTRODUCTION
    CEROTTINI, JC
    MACDONALD, HR
    ANNALES DE L INSTITUT PASTEUR-IMMUNOLOGY, 1987, 138 (02): : 289 - 289
  • [40] Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes
    Zhang, Zheng
    He, Qi
    Tao, Ying
    Guo, Juan
    Xu, Feng
    Wu, Ling-Yun
    Zhao, You-Shan
    Wu, Dong
    Zhou, Li-Yu
    Su, Ji-Ying
    Song, Lu-Xi
    Xiao, Chao
    Li, Xiao
    Chang, Chun-Kang
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2017, 9 (02): : 454 - 465
12345