A one-pot synthesis of unsymmetrical and symmetrical tetrasubstituted alpha-fluoro-alpha beta-unsaturated esters

被引：12

作者：

Tsai, HJ ^{[1
]}

Thenappan, A ^{[1
]}

Burton, DJ ^{[1
]}

机构：

[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1995年 / 105卷 / 1-4期

基金：

美国国家科学基金会;

关键词：

beta-ketophosphonates; betaine; phosgene; perfluorinated Grignard reagents; Emmons reaction; olefins;

D O I：

10.1080/10426509508042064

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Acylation of [(EtO)(2)P(O)CFCO(2)Et]Li--(+) 1 with acid chlorides RC(O)Cl or phosgene CIC(O)Cl and subsequent reaction of the acylated phosphonate with organometallic reagents (R'M) provide unsymmetrical and symmetrical tetrasubstituted alpha-fluoro-alpha,beta-unsaturated esters, RR'C=CFCO(2)Et and R(2)'=CFCO(2)Et, in moderate to good yields.

引用

页码：205 / 212

页数：8

共 50 条

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