A one-pot synthesis of unsymmetrical and symmetrical tetrasubstituted alpha-fluoro-alpha beta-unsaturated esters

被引：12
|
作者：
Tsai, HJ [1 ]
Thenappan, A [1 ]
Burton, DJ [1 ]
机构：
[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1995年 / 105卷 / 1-4期
基金：
美国国家科学基金会;
关键词：
beta-ketophosphonates; betaine; phosgene; perfluorinated Grignard reagents; Emmons reaction; olefins;
D O I：
10.1080/10426509508042064
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Acylation of [(EtO)(2)P(O)CFCO(2)Et]Li--(+) 1 with acid chlorides RC(O)Cl or phosgene CIC(O)Cl and subsequent reaction of the acylated phosphonate with organometallic reagents (R'M) provide unsymmetrical and symmetrical tetrasubstituted alpha-fluoro-alpha,beta-unsaturated esters, RR'C=CFCO(2)Et and R(2)'=CFCO(2)Et, in moderate to good yields.
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页码：205 / 212
页数：8
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