ISOLATION AND CHARACTERIZATION OF A GENE FOR A RYANODINE RECEPTOR CALCIUM-RELEASE CHANNEL IN DROSOPHILA-MELANOGASTER

被引：141
|
作者：
TAKESHIMA, H
NISHI, M
IWABE, N
MIYATA, T
HOSOYA, T
MASAI, I
HOTTA, Y
机构：
[1] KYOTO UNIV,FAC SCI,DEPT BIOPHYS,KYOTO 60601,JAPAN
[2] UNIV TOKYO,FAC SCI,DEPT PHYS,TOKYO 113,JAPAN
[3] UNIV TOKYO,MOLEC GENET RES LAB,TOKYO 113,JAPAN
[4] NATL INST BASIC BIOL,OKAZAKI,AICHI 444,JAPAN
来源：
FEBS LETTERS | 1994年 / 337卷 / 01期
关键词：
RYANODINE RECEPTOR; CALCIUM RELEASE CHANNEL; DROSOPHILA; RNA BLOT HYBRIDIZATION; CHROMOSOMAL MAPPING;
D O I：
10.1016/0014-5793(94)80634-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The nucleotide sequence of a 25.7 kilobase Drosophila melanogaster genomic DNA segment containing a gene for a ryanodine receptor/calcium release channel homologue has been determined. Computer analysis and partial cDNA cloning revealed 26 exons comprising the protein-coding sequence in this gene. The predicted protein is homologous in amino acid sequence and shares characteristic structural features with the mammalian ryanodine receptors. In blot hybridization analysis, a similar to 16 kilobase RNA species was identified abundantly in a 6-12 h embryo as the transcript from this gene. In situ hybridization to polytene chromosomes indicated that this gene locates at band position 44F on the second chromosome.
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页码：81 / 87
页数：7
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