SIMULTANEOUS CHANGES IN HYPOTHALAMIC CATECHOLAMINE LEVELS AND PLASMA-CORTICOSTERONE CONCENTRATION IN THE RAT AFTER ACUTE MORPHINE AND DURING TOLERANCE

被引：27

作者：

MILANES, MV ^{[1
]}

PUIG, MM ^{[1
]}

VARGAS, ML ^{[1
]}

机构：

[1] HOSP MARE DEU ESPERANCA,DEPT ANAESTHESIA,BARCELONA,SPAIN

来源：

NEUROPEPTIDES | 1993年 / 24卷 / 05期

关键词：

D O I：

10.1016/0143-4179(93)90016-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of morphine on plasma corticosterone and hypothalamic noradrenaline (NA) and dopamine (DA) content were studied in naive and in morphine-tolerant rats. Acutely administered morphine (30 mg/kg i.p.) significantly increased the plasma levels of corticosterone and significantly reduced the hypothalamic NA and DA content. In chronically morphine-treated rats (subcutaneously implanted with pellets for 7 days), a challenge dose of morphine (30 mg/kg intraperitoneally (i.p.)) did not modify the plasma corticosterone levels and inhibited the morphine-induced decreases in hypothalamic NA and DA content. These results suggest that: (1) In naive rats, the morphine-induced activation of hypothalamus- pituitary- adrenocortical (HPA) axis is mediated by catecholaminergic neurons in the hypothalamus; (2) In tolerant rats morphine did not modify the plasma corticosterone concentrations, presumably by attenuating hypothalamic noradrenergic and dopaminergic activity. (3) Hypothalamic catecholamines have a role in regulating the HPA axis during morphine tolerance.

引用

页码：279 / 284

页数：6