A CONVENIENT SYNTHESIS OF SUBSTITUTED PYRROLES FROM ESTERS OF AMINO-ACIDS

被引:14
|
作者
KOLAR, P [1 ]
TISLER, M [1 ]
机构
[1] UNIV LJUBLJANA,FAC NAT SCI & TECHNOL,DEPT CHEM,LJUBLJANA 61000,SLOVENIA
关键词
D O I
10.1080/00397919408010197
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new simple synthesis of substituted pyrroles from alkyl, aryl or heteroaryl substituted alpha-amino acids is described. Esters of alpha-amino acids are first reacted with dimethyl acetylenedicarboxylate and in the in situ formed enamines are thereafter cyclized in presence of sodium methoxide to pyrroles.
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页码:1887 / 1893
页数:7
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