ELECTRON-IMPACT INDUCED LOSS OF C-5/C-8 SUBSTITUENTS OF 1,2,3,4-TETRAHYDROISOQUINOLINES .6. SYNTHESIS AND MASS-SPECTROMETRIC FRAGMENTATION OF DIHYDROINDOLE DERIVATIVES

被引：3

作者：

KNEFELI, F ^{[1
]}

MAYER, KK ^{[1
]}

WIEGREBE, W ^{[1
]}

SCHLUNEGGER, UP ^{[1
]}

LAUBER, R ^{[1
]}

机构：

[1] UNIV BERN,INST ORGAN CHEM,CH-3000 BERN,SWITZERLAND

来源：

ARCHIV DER PHARMAZIE | 1990年 / 323卷 / 03期

关键词：

D O I：

10.1002/ardp.19903230305

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses of the C‐4 substituted dihydroindoles 25, 31 (scheme 7), and 36 (scheme 8) are described. ‐ The CID MIKE spectrum in the 2. field free region (2. FFR) of m/z 146 from 25 is very similar to but not identical with that of m/z 146 from the C‐5 substituted tetrahydroisoquinolines 3, 6, 7, and 8 (scheme 2), so supporting our hypothesis of a rearrangement in M+ of tetrahydroisoquinolines1) prior to fragmentation, but not proving it. As the CID MIKE spectra of the tetrahydroisoquinolines 3, 6, 7, and 8 are not identical among each other we assume that a 1.3‐H‐shift takes places in their M+ in competition to the rearrangement mentioned above. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：145 / 155

页数：11

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