CRYSTAL AND MOLECULAR-STRUCTURES OF 1-(2-ETHYLOXYCARBONYLO PROPAN-2-YLAMINO)-3-(1-NAPTHYLOXY) PROPAN-2-OL-HYDROCHLORIDE (1) (C19H26NO4CL) AND 1-(2-ISOPROPYLOXYCARBONYLO-PROPAN-2-YLAMINO)-3-(1-NAPTHYLOXY) PROPAN-2-OL HYDROCHLORIDE (2) (C20H28NO4CL)

The crystal structures of two new beta-adrenergic antagonists, derivatives of propranolol, are shown in this paper. The space groups and unit-cell parameters are: compound 1 (C19H26NO4Cl): triclinic, space group P1, a = 6.420(1), b = 10.161(1), c = 15.823(1) angstrom, alpha = 82.47(1), beta = 84.16(1), gamma = 77.55(1)-degrees; compound 2 (C20H28NO4Cl): monoclinic, space group P2(1)/c, a = 6.460(1), b = 33.285(2), c = 10.120(1) angstrom, beta = 104.83(1)-degrees. The structures were solved by direct methods and refined with full-matrix least-squares techniques to R indices of 0.055 and 0.048, respectively. The -CH(OH)-CH2-NH-sections of the side chains show the conformation approximate to gauche.