COMPARING THE QUALITY-ADJUSTED LIFE-YEAR OUTPUT OF 2 TREATMENT ARMS IN A RANDOMIZED TRIAL

被引：0
|
作者：
GANIATS, TG [1 ]
MILLER, CJ [1 ]
KAPLAN, RM [1 ]
机构：
[1] UNIV CALIF SAN DIEGO, HLTH OUTCOMES ASSESSMENT PROGRAM, LA JOLLA, CA 92093 USA
来源：
MEDICAL CARE | 1995年 / 33卷 / 04期
关键词：
QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIALS; DATA INTERPRETATION; STATISTICAL; QUALITY-ADJUSTED LIFE YEARS;
D O I：
暂无
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
The quality-adjusted life year (QALY) is an outcome measure with two dimensions: wellness and time. It is difficult to compare the QALY output of two groups when subjects are observed for varying time periods, because both elements of the two-dimensional outcome measure vary in all subjects. This paper evaluates the strengths and weaknesses of five approaches for making these comparisons. These approaches are: a subject-based approach, the elimination of time, calculation of the mean of available data, use of quality-adjusted survival analysis, and calculation of a maximum likelihood estimation. It is concluded that the maximum likelihood estimation offers significant advantages over the other methods.
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收藏
页码：AS245 / AS254
页数：10
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