BENZAMIDE-INDUCED CHANGES IN THE ACTIN CYTOSKELETON IN HUMAN SKIN FIBROBLASTS

被引：5
|
作者：
KOROHODA, W
MICHALIK, M
PIERZCHALSKA, M
机构：
[1] Department of Cell Biology, Jan Zurzycki Institute of Molecular Biology, Jagiellonian University, 31-120 Kraków
来源：
CELL BIOLOGY INTERNATIONAL | 1994年 / 18卷 / 08期
关键词：
D O I：
10.1006/cbir.1994.1111
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The incubation of human skin fibroblasts in the presence of 10 mM benzamide in Joklik's modification of Eagle's Minimal Essential Medium caused an extensive reorganization of actin filaments. The disappearance of stress fibers and changes in cell morphology were observed, whereas no changes in the microtubule architecture were noticed. The observed effects appeared fully reversible within 3 hours after the removal of benzamide. The results are discussed in relation to the two known activities of benzamide as an anaesthetic and an inhibitor of ADP-ribosylation.
引用
收藏
页码：791 / 796
页数：6
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