BETA-AMYLOID PROTEIN-INDUCED ALZHEIMERS-DISEASE ANIMAL-MODEL

被引：253
|
作者：
NITTA, A
ITOH, A
HASEGAWA, T
NABESHIMA, T
机构：
[1] NAGOYA UNIV,SCH MED,DEPT NEUROPSYCHOPHARMACOL,SHOWA KU,NAGOYA,AICHI 466,JAPAN
[2] NAGOYA UNIV,HOSP PHARM,SCH MED,SHOWA KU,NAGOYA,AICHI 466,JAPAN
来源：
NEUROSCIENCE LETTERS | 1994年 / 170卷 / 01期
关键词：
BETA-AMYLOID PROTEIN; ALZHEIMERS DISEASE; MEMORY; CHOLINE ACETYLTRANSFERASE; WATER MAZE; RAT;
D O I：
10.1016/0304-3940(94)90239-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To investigate the toxicity of beta-amyloid protein which consisted of senile plaques of Alzheimer's disease (AD), this was infused into cerebral ventricle for 14 days by using mini-osmotic pump. The performance of the water maze task in beta-amyloid protein-treated rats was impaired. Choline acetyltransferase activity significantly decreased in the frontal cortex and hippocampus. These results suggest that the deposition of beta-amyloid protein in the brain is related to the impairment of learning and cholinergic neuronal degeneration, and that beta-amyloid protein-treated rats could be used as an animal model for AD.
引用
收藏
页码：63 / 66
页数：4
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