SUGAR MODIFIED OLIGONUCLEOTIDES - SYNTHESIS, NUCLEASE RESISTANCE AND BASE-PAIRING OF OLIGODEOXYNUCLEOTIDES CONTAINING 1-(4'-THIO-BETA-D-RIBOFURANOSYL)-THYMINE

被引：17

作者：

BELLON, L

MORVAN, F

BARASCUT, JL

IMBACH, JL

机构：

[1] Université de Montpellier II Sciences et Techniques du Languedoc, Laboratoire de Chimie Bio-Organique, URA 488 du CNRS, 34095 Montpellier cédex 5, Place E. Bataillon

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90660-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

XdT12 and dT5XdT6, where X is 1-(4′-thio-β-d-ribofuranosyl)-thymine, were synthesized. The first oligonucleotide presents a better stability against calf spleen phosphodiesterase than natural dT12. The second one hybridizes with complementary sequence. However the X:A base pairing stability is lower than natural T:A one. © 1992.

引用

页码：797 / 803

页数：7

共 13 条

[11] SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING 1-(BETA-D-3'-DEOXY-THREO-PENTOFURANOSYL)PYRIMIDINES AND THEIR RESISTANCE TO THE ACTION OF SNAKE-VENOM PHOSPHODIESTERASE
ORETSKAYA, TS
IBRAGIM, HKH
VOLKOV, EM
ROMANOVA, EA
TASHLITSKY, VN
SHABAROVA, ZA
BIOORGANICHESKAYA KHIMIYA, 1994, 20 (8-9): : 967 - 974
[12] SYNTHESIS OF (1-[2',5'-BIS-O-(T-BUTYLDIMETHYLSILYL)-BETA-D-XYLO AND BETA-D-RIBOFURANOSYL]THYMINE)-3'-SPIRO-5''-(4''-AMINO-1'',2''-OXATHIOLE-2'',2''-DIOXIDE) (TSAO) - A NOVEL TYPE OF SPECIFIC ANTI-HIV AGENTS
PEREZPEREZ, MJ
SANFELIX, A
CAMARASA, MJ
BALZARINI, J
DECLERCQ, E
TETRAHEDRON LETTERS, 1992, 33 (21) : 3029 - 3032
[13] TSAO ANALOGS - STEREOSPECIFIC SYNTHESIS AND ANTI-HIV-1 ACTIVITY OF 1-[2',5'-BIS-0-(TERT-BUTYLDIMETHYLSILYL)-BETA-D-RIBOFURANOSYL]-3'-SPIRO-5''-(4''-AMINO-1'',2''-OXATHIOLE 2'',2''-DIOXIDE)PYRIMIDINE AND PYRIMIDINE-MODIFIED NUCLEOSIDES
PEREZPEREZ, MJ
SANFELIX, A
BALZARINI, J
DECLERCQ, E
CAMARASA, MJ
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (16) : 2988 - 2995

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