SUGAR MODIFIED OLIGONUCLEOTIDES - SYNTHESIS, NUCLEASE RESISTANCE AND BASE-PAIRING OF OLIGODEOXYNUCLEOTIDES CONTAINING 1-(4'-THIO-BETA-D-RIBOFURANOSYL)-THYMINE

被引：17
|
作者：
BELLON, L
MORVAN, F
BARASCUT, JL
IMBACH, JL
机构：
[1] Université de Montpellier II Sciences et Techniques du Languedoc, Laboratoire de Chimie Bio-Organique, URA 488 du CNRS, 34095 Montpellier cédex 5, Place E. Bataillon
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 02期
关键词：
D O I：
10.1016/0006-291X(92)90660-D
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
XdT12 and dT5XdT6, where X is 1-(4′-thio-β-d-ribofuranosyl)-thymine, were synthesized. The first oligonucleotide presents a better stability against calf spleen phosphodiesterase than natural dT12. The second one hybridizes with complementary sequence. However the X:A base pairing stability is lower than natural T:A one. © 1992.
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页码：797 / 803
页数：7
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