IMPAIRED RESPONSE TO HEPATITIS-B VACCINE IN HIV INFECTED CHILDREN

被引：54

作者：

ZUIN, G ^{[1
]}

PRINCIPI, N ^{[1
]}

TORNAGHI, R ^{[1
]}

PACCAGNINI, S ^{[1
]}

RE, M ^{[1
]}

MASSIRONI, E ^{[1
]}

RAGNI, MC ^{[1
]}

机构：

[1] OSPED L SACCO,MICROBIOL LAB,I-20157 MILAN,ITALY

来源：

VACCINE | 1992年 / 10卷 / 12期

关键词：

HUMAN IMMUNODEFICIENCY VIRUS (HIV); HEPATITIS-B VACCINE; IMPAIRED RESPONSE; CHILDREN;

D O I：

10.1016/0264-410X(92)90050-T

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Eighteen human immunodeficiency virus (HIV) vertically infected children (HIV group) and 33 seroreverted children (SR group), who had completed hepatitis B vaccination (Engerix B, 20-mu-g dose) were studied. Four out of 18 (22%) HIV children failed to develop protective antibody levels (anti-HBs titres < 10 mIU ml-1) compared with 1 out of 33 (3%) SR children (p < 0.05). Magnitude of response among HIV children was significantly lower than among SR children. In HIV children the probability that anti-HBs titres persist above the protective levels was significantly lower than in the SR group at any time during the 24 month follow-up. These results show that HIV children have a suboptimal response to hepatitis B immunization and the protection is less durable. Further studies are needed to determine the optimal protocol for hepatitis B immunization in HIV children.

引用

页码：857 / 860

页数：4

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