CALCIUM-MODULATED INWARD RECTIFICATION OF A CALCIUM-ACTIVATED POTASSIUM CHANNEL IN NEURONS

被引：5
|
作者：
KANG, J [1 ]
SUMNERS, C [1 ]
POSNER, P [1 ]
机构：
[1] UNIV FLORIDA, COLL MED, DEPT PHYSIOL, GAINESVILLE, FL 32610 USA
来源：
JOURNAL OF NEUROPHYSIOLOGY | 1994年 / 72卷 / 06期
关键词：
D O I：
10.1152/jn.1994.72.6.3023
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
1. Inward rectification of a calcium-activated K+ channel in neurons cultured from the hypothalamus and brain stem of 1-day-old rats was studied by using patch-clamp techniques. A big conductance calcium-activated K+ channel with a slow gating rate was observed in inside-out patches. With symmetrical K+ across patches, inward conductance of this calcium-activated K+ channel was 216 +/- 14 (SE) pS (n=4 patches), which changed little as different [Ca2+] was included in the bath solution. Outward conductance of this calcium-activated K+ channel was regulated by [Ca2+] in the bath solution and was 74 +/- 15 pS with 500 muM Ca2+. The higher level of Ca2+ on the intracellular side of the membrane caused the larger degree of rectification. Mg2+ only had a minor effect on rectification of this calcium-activated K+ channel.
引用
收藏
页码：3023 / 3025
页数：3
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