PLASMA ARGININE VASOPRESSIN AND THE SYNDROME OF INAPPROPRIATE ANTIDIURETIC-HORMONE SECRETION IN TUBERCULOUS MENINGITIS

被引:23
|
作者
COTTON, MF
DONALD, PR
SCHOEMAN, JF
AALBERS, C
VANZYL, LE
LOMBARD, C
机构
[1] UNIV STELLENBOSCH,DEPT PEDIAT & CHILD HLTH,PAROWVALLEI,SOUTH AFRICA
[2] UNIV STELLENBOSCH,DEPT CHEM PATHOL,PAROWVALLEI,SOUTH AFRICA
[3] TYGERBERG HOSP,INST BIOSTAT,MRC,PAROWVALLEI,SOUTH AFRICA
关键词
PLASMA ARGININE VASOPRESSIN; SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION; TUBERCULOUS MENINGITIS; CHILDREN;
D O I
10.1097/00006454-199111000-00009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Biochemical evidence of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) was documented in 17 of 24 (71%) children with tuberculous meningitis. Plasma arginine vasopressin concentrations in patients with signs of SIADH were significantly higher (median, 15.44 (range, 1.62 to > 24.52) pg/ml; n = 14) than those without (median, 1.91 (range, 0.44 to 4.91) pg/ml; n = 6) (P < 0.002). Patients who developed evidence of SIADH were older than those who did not (median, 34 (range, 6 to 101) months vs. 10 (range, 6 to 38) months; P < 0.007). Five patients with and none without died. In 9 patients evidence of SIADH developed only after hospitalization. These patients received a median of 58 (range, 28 to 109) ml/kg/day fluids (n = 7) before developing evidence of SIADH compared with 107 (range, 58 to 146) ml/kg/day received by patients who did not develop SIADH (n = 6) (P = 0.035). SIADH occurs commonly and its presence appears to influence the outcome of tuberculous meningitis in children.
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页码:837 / 842
页数:6
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