SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME HALO-SUBSTITUTED AND TRIFLUOROMETHYL-SUBSTITUTED PHENYLCEPHALOSPORINS AND PHENYLDEACETOXYCEPHALOSPORINS

被引：0
|
作者：
KOBAL, E
VALENCIC, M
TISLER, V
VITEZIC, N
JAPELJ, M
机构：
[1] EDVARD KARDELJ UNIV, FAC NAT SCI & TECHNOL, YU-61000 LJUBLJANA, SLOVENIA
[2] RES & DEV INST KRKA, PHARMACEUT & CHEM WORKS, YU-68000 NOVO MESTO, SLOVENIA
[3] EDVARD KARDELJ UNIV, DEPT CHEM & CHEM TECHNOL, YU-61000 LJUBLJANA, SLOVENIA
来源：
ACTA PHARMACEUTICA | 1992年 / 42卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The synthesis and in vitro antibacterial activity of some halo- and trifluoromethyl-substituted phenylcephalosporins and substituted phenyldeacetoxycephalosporins are described. The dilution method [minimal inhibitory concentration, MIC (mu-g ml-1)] was used to test the synthesized compounds. We were interested in the following questions: 1. Is this type of substances highly active only against Gram-positive organisms? 2. Which halogen and which positions of halogen are especially favorable?
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页码：59 / 67
页数：9
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