The sevenless protein tyrosine kinase receptor plays a central role in the pathway of cell fate induction that determines the development of the R7 photoreceptor in the Drosophila eye. In the last year we have learned much about the probable ligand for sevenless and have begun to dissect the signal transduction pathway that relays the information from the sevenless kinase. Studies of the mechanisms governing the specificity of signal transmission and reception suggest that the sevenless signal directs a bipotential cell towards a neuronal rather than a cone cell fate.
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NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USANYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
Douthit, Jessica
Hairston, Ariel
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NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USANYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
Hairston, Ariel
Lee, Gina
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NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USANYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
Lee, Gina
Morrison, Carolyn A.
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NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USANYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
Morrison, Carolyn A.
Holguera, Isabel
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NYU, Dept Biol, New York, NY 10003 USANYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
Holguera, Isabel
Treisman, Jessica E.
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NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA
NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USANYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst, New York, NY 10016 USA