DEVELOPMENT OF GLUCOSE-INTOLERANCE IN OBESE (FA FA) ZUCKER RATS

被引：24
|
作者：
APWEILER, R
FREUND, P
机构：
[1] BOEHRINGER MANNHEIM GERMANY,DEPT MED RES DIABET,SANDHOFERSTR 116,D-68305 MANNHEIM,GERMANY
[2] BOEHRINGER MANNHEIM GMBH,DEPT MED RES,W-6800 MANNHEIM 31,GERMANY
[3] ZENTRUM MOLEK BIOL HEIDELBERG,HEIDELBERG,GERMANY
来源：
HORMONE AND METABOLIC RESEARCH | 1993年 / 25卷 / 10期
关键词：
INSULIN RESISTANCE; OBESITY; GLUCOSE INTOLERANCE; OGTT; FA FA RATS;
D O I：
10.1055/s-2007-1002165
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Development of glucose intolerance in genetically obese (fa/fa) rats was investigated. Comparisons were made with lean (FA/?) control rats. Oral glucose tolerance tests were performed in 7-8 weeks, 9-10 weeks, 12-13 weeks and 16-17 weeks old rats. Irrespectively of age, the obese rats showed impaired glucose tolerance and insulin sensitivity compared with age-matched lean rats. While in FA/? rats only minor changes of glucose-stimulated insulin secretion and glucose tolerance were observed with progression of age, glucose intolerance in obese animals became more pronounced with aging. Obese rats older than 12-13 weeks showed no further progression of glucose intolerance. Glucose-stimulated insulin secretion increased with aging, but basal insulinemia was unaffected. Hence, we conclude that glucose intolerance and insulin resistance in genetically obese (fa/fa) rats is almost completely developed with approximately 12 weeks.
引用
收藏
页码：521 / 524
页数：4
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