DEVELOPMENT OF GLUCOSE-INTOLERANCE IN OBESE (FA FA) ZUCKER RATS

被引：24
|
作者：
APWEILER, R
FREUND, P
机构：
[1] BOEHRINGER MANNHEIM GERMANY,DEPT MED RES DIABET,SANDHOFERSTR 116,D-68305 MANNHEIM,GERMANY
[2] BOEHRINGER MANNHEIM GMBH,DEPT MED RES,W-6800 MANNHEIM 31,GERMANY
[3] ZENTRUM MOLEK BIOL HEIDELBERG,HEIDELBERG,GERMANY
来源：
HORMONE AND METABOLIC RESEARCH | 1993年 / 25卷 / 10期
关键词：
INSULIN RESISTANCE; OBESITY; GLUCOSE INTOLERANCE; OGTT; FA FA RATS;
D O I：
10.1055/s-2007-1002165
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Development of glucose intolerance in genetically obese (fa/fa) rats was investigated. Comparisons were made with lean (FA/?) control rats. Oral glucose tolerance tests were performed in 7-8 weeks, 9-10 weeks, 12-13 weeks and 16-17 weeks old rats. Irrespectively of age, the obese rats showed impaired glucose tolerance and insulin sensitivity compared with age-matched lean rats. While in FA/? rats only minor changes of glucose-stimulated insulin secretion and glucose tolerance were observed with progression of age, glucose intolerance in obese animals became more pronounced with aging. Obese rats older than 12-13 weeks showed no further progression of glucose intolerance. Glucose-stimulated insulin secretion increased with aging, but basal insulinemia was unaffected. Hence, we conclude that glucose intolerance and insulin resistance in genetically obese (fa/fa) rats is almost completely developed with approximately 12 weeks.
引用
收藏
页码：521 / 524
页数：4
相关论文
共 50 条
  • [1] MECHANISM OF GLUCOSE-INTOLERANCE IN GENETICALLY-OBESE (FA/FA) RATS
    ROHNERJEANRENAUD, F
    IONESCU, E
    PROIETTO, J
    JEANRENAUD, B
    [J]. DIABETES & METABOLISM, 1986, 12 (05): : 290 - 290
  • [2] PANCREATIC HYPERSENSITIVITY TO GLUCOSE BY YOUNG OBESE ZUCKER RATS (FA/FA)
    KUFFERT, A
    STERN, JS
    CURRY, DL
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1988, 37 (10): : 952 - 957
  • [3] Effect of sibutramine on glucose metabolism in genetically obese (fa/fa) Zucker rats
    Fabris, R
    Granzotto, M
    Pagano, C
    Lombardi, AM
    Ferretti, E
    Marzolo, M
    Scagnol, I
    Federspil, G
    Vettor, R
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (Suppl 2) : S124 - S126
  • [4] EVIDENCE FOR DEFECTIVE GLUCOSE SENSING BY ISLETS OF FA FA OBESE ZUCKER RATS
    CHAN, CB
    MACPHAIL, RM
    MITTON, K
    [J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1993, 71 (01) : 34 - 39
  • [5] Effect of sibutramine on glucose metabolism in genetically obese (fa/fa) Zucker rats
    R Fabris
    M Granzotto
    C Pagano
    AM Lombardi
    E Ferretti
    M Marzolo
    I Scagnol
    G Federspil
    R Vettor
    [J]. International Journal of Obesity, 2000, 24 : S124 - S126
  • [6] BENEFICIAL EFFECT OF INTRAVENOUS BOLUS OF CORTICOTROPIN-RELEASING FACTOR ON GLUCOSE-INTOLERANCE OF GENETICALLY-OBESE (FA/FA) RATS
    ROHNERJEANRENAUD, F
    JEANRENAUD, B
    [J]. DIABETES, 1992, 41 (04) : 493 - 498
  • [7] Rodent Plasmodium development in livers of genetically obese Zucker rats (fa/fa)
    Lombard, MN
    Bazin, R
    Durand, G
    Beauge, F
    Baccam, D
    Milgen, F
    Landau, I
    [J]. EUROPEAN JOURNAL OF PROTISTOLOGY, 1998, 34 (01) : 78 - 81
  • [8] DEHYDROEPIANDROSTERONE AND MACRONUTRIENT SELECTION BY OBESE ZUCKER RATS (FA/FA)
    SVEC, F
    ABADIE, J
    BROWNE, ES
    PORTER, JR
    [J]. APPETITE, 1995, 25 (02) : 143 - 154
  • [9] Hepatic denervation and dyslipidemia in obese Zucker (fa/fa) rats
    Bruinstroop, E.
    Eliveld, J.
    Foppen, E.
    Busker, S.
    Ackermans, M. T.
    Fliers, E.
    Kalsbeek, A.
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2015, 39 (11) : 1655 - 1658
  • [10] Hepatic denervation and dyslipidemia in obese Zucker (fa/fa) rats
    E Bruinstroop
    J Eliveld
    E Foppen
    S Busker
    M T Ackermans
    E Fliers
    A Kalsbeek
    [J]. International Journal of Obesity, 2015, 39 : 1655 - 1658
12345