SYNTHESIS OF SOME NEW ISOXAZOLYLACETIC ACID-DERIVATIVES

被引：13
|
作者：
GOMBOS, Z
NYITRAI, J
DOLESCHALL, G
KOLONITS, P
PARKANYI, L
KALMAN, A
机构：
[1] TECH UNIV BUDAPEST,DEPT ORGAN CHEM,H-1521 BUDAPEST,HUNGARY
[2] HUNGARIAN ACAD SCI,ALKALOID CHEM RES GRP,H-1521 BUDAPEST,HUNGARY
[3] HUNGARIAN ACAD SCI,CENT RES INST CHEM,H-1525 BUDAPEST,HUNGARY
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 01期
关键词：
D O I：
10.1039/p19930000139
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(3-Chloroisoxazol-5-yl)acetic acid 1, a known acylating agent, useful for the synthesis of semi-synthetic cephalosporins was synthesized by a new route. Several alpha-substituted 3-chloroisoxazolylacetic acids 9a, b; 10a, b and 1 5, potential acylating agents for semi-synthetic beta-lactams, were also prepared. The (E) -and (Z)-3-chloro-alpha-methoxyiminoisoxazol-5-ylacetic acids 10a, b were separated and their structures unambiguously determined by H-1 NMR spectroscopic and X-ray measurements.
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页码：139 / 143
页数：5
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