AUTORADIOGRAPHIC LOCALIZATION OF BINDING-SITES FOR NEUROPEPTIDE-Y AND BRADYKININ ON ASTROCYTES

被引：0

作者：

HOSLI, E ^{[1
]}

HOSLI, L ^{[1
]}

机构：

[1] UNIV BASEL,DEPT PHYSIOL,VESALGASSE 1,CH-4051 BASEL,SWITZERLAND

来源：

NEUROREPORT | 1993年 / 4卷 / 02期

关键词：

AUTORADIOGRAPHY; ASTROCYTES; NEUROPEPTIDE-Y; BRADYKININ; TISSUE CULTURE; CEREBELLUM; BRAIN STEM; SPINAL CORD;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE cellular localization of binding sites for the vasoactive peptides I-125-neuropeptide Y (NPY) and H-3-bradykinin (BK) was studied in explant cultures of rat cerebellum, brain stem and spinal cord by means of autoradiography. The majority of astrocytes in these cultures expressed binding of I-125-NPY and H-3-BK over their cell bodies and processes. Simultaneous staining of the cultures with antiglial fibrillary acidic protein (GFAP) has shown that the labelled cells were GFAP-positive and could therefore be identified as astrocytes. In addition to glial cells, a great number of neurones also revealed binding sites for the neuropeptides. Our autoradiographic findings together with recent electrophysiological studies provide good evidence for the existence of NPY- and BK-receptors on astrocytes.

引用

页码：159 / 162

页数：4

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