CONCURRENT USE OF GRANULOCYTE-COLONY-STIMULATING FACTOR WITH LOW-DOSE CYTOSINE-ARABINOSIDE AND ACLARUBICIN FOR PREVIOUSLY TREATED ACUTE MYELOGENOUS LEUKEMIA - A PILOT-STUDY

We used a new chemotherapy regimen for the treatment of 18 consecutive patients with relapsed AML (median age 44 years, range 18-74). The regimen consisted of low-dose cytosine arabinoside (10 mg/m(2)/12 h, usually day 1 to 14), low-dose aclarubicin (10-14 mg/m(2)/day, day 1 to 4), and concurrent use of G-CSF (200 mu g/m(2)/day) (GAG regimen). Overall, 15/18 patients (83%) achieved complete remission (CR) after one or two courses, including eight out of ten refractory patients with early relapse, second or subsequent relapses, and/or resistant relapse. Two of three patients who relapsed, achieved CR again after reinduction with a modified CAG regimen. Fourteen of the 15 complete remitters received consolidation therapy with the CAG regimen modified, followed by oral busulfan in eight cases, and by allogeneic bone marrow transplantation in two cases. At a median follow-up of 12 months, median CR duration and survival were 6 months and 17 months, respectively. Myelosuppression in the first course of induction therapy was moderate to severe. However, severe non-hematologic toxicity (WHO grade greater than or equal to 3) was characteristically rare. Although this is a preliminary study, the CAG combination seems promising for the treatment of relapsed AML, with its low toxicity contributing to a higher quality of life for the patient.