PROGRESS IN ANTI-HIV STRUCTURE-BASED DRUG DESIGN

被引：52
|
作者：
GAIT, MJ
KARN, J
机构：
[1] The MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills Road
来源：
TRENDS IN BIOTECHNOLOGY | 1995年 / 13卷 / 10期
关键词：
D O I：
10.1016/S0167-7799(00)88998-2
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The course of drug development for the treatment of HIV-1 infection and AIDS is being revolutionized by high-resolution structures of essential viral proteins. We survey the impact on drug design of the recently elucidated structural knowledge of two essential enzymes, reverse transcriptase and protease, and three new targets, the viral integrase and the gene regulatory protein-RNA interactions, Tat-TAR and ReV-RRE.
引用
收藏
页码：430 / 438
页数：9
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