CHEMISTRY OF PEPTIDE INTERACTIONS WITH MHC PROTEINS

被引:34
|
作者
SETTE, A
GREY, HM
机构
[1] Cytel, San Diego, CA
关键词
D O I
10.1016/0952-7915(92)90130-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
X-ray crystallographic and peptide-MHC binding studies have begun to clarify the interaction between antigenic peptides and MHC proteins at the molecular level. At the same time, our understanding of the mechanisms of peptide-MHC interactions in physiologic cellular conditions has been significantly expanded by the isolation and characterization of naturally processed antigenic peptides.
引用
收藏
页码:79 / 86
页数:8
相关论文
共 50 条
  • [31] Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex
    Tissot, AC
    Ciatto, C
    Mittl, PRE
    Grütter, MG
    Plückthun, A
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2000, 302 (04) : 873 - 885
  • [32] Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility
    Ayres, Cory M.
    Abualrous, Esam T.
    Bailey, Alistair
    Abraham, Christian
    Hellman, Lance M.
    Corcelli, Steven A.
    Noe, Frank
    Elliott, Tim
    Baker, Brian M.
    [J]. FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [33] Binding peptide generation for MHC Class I proteins with deep reinforcement learning
    Chen, Ziqi
    Zhang, Baoyi
    Guo, Hongyu
    Emani, Prashant
    Clancy, Trevor
    Jiang, Chongming
    Gerstein, Mark
    Ning, Xia
    Cheng, Chao
    Min, Martin Renqiang
    [J]. BIOINFORMATICS, 2023, 39 (02)
  • [34] Deriving matrix of peptide-MHC interactions in diabetic mouse by genetic algorithm
    Rajapakse, M
    Wyse, L
    Schmidt, B
    Brusic, V
    [J]. INTELLIGENT DATA ENGINEERING AND AUTOMATED LEARNING IDEAL 2005, PROCEEDINGS, 2005, 3578 : 440 - 447
  • [35] Trans-Allelic Model for Prediction of Peptide:MHC-II Interactions
    Degoot, Abdoelnaser M.
    Chirove, Faraimunashe
    Ndifon, Wilfred
    [J]. FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [36] Strength of TCR-Peptide/MHC Interactions and In Vivo T Cell Responses
    Corse, Emily
    Gottschalk, Rachel A.
    Allison, James P.
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 186 (09): : 5039 - 5045
  • [37] TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity
    Johannes B. Huppa
    Markus Axmann
    Manuel A. Mörtelmaier
    Björn F. Lillemeier
    Evan W. Newell
    Mario Brameshuber
    Lawrence O. Klein
    Gerhard J. Schütz
    Mark M. Davis
    [J]. Nature, 2010, 463 : 963 - 967
  • [38] Predicting interactions between T cell receptors and MHC-peptide complexes
    Roomp, Kirsten
    Domingues, Francisco S.
    [J]. MOLECULAR IMMUNOLOGY, 2011, 48 (04) : 553 - 562
  • [39] Interactions of TCRs with MHC-peptide complexes: A quantitative basis for mechanistic models
    Margulies, DH
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1997, 9 (03) : 390 - 395
  • [40] INTERACTIONS OF A FLUORESCENTLY LABELED PEPTIDE WITH KRINGLE DOMAINS IN PROTEINS
    BALCIUNAS, A
    FLESS, GM
    SCANU, AM
    COPELAND, RA
    [J]. JOURNAL OF PROTEIN CHEMISTRY, 1993, 12 (01): : 39 - 43