CHARACTERIZATION OF THE AMYLOID FIBRIL FROM PRIMARY LOCALIZED CUTANEOUS NODULAR AMYLOIDOSIS ASSOCIATED WITH SJOGRENS-SYNDROME

被引：25

作者：

INAZUMI, T

HAKUNO, M

YAMADA, H

TANAKA, M

NAKA, W

TAJIMA, S

HARADA, T

NISHIKAWA, T

机构：

[1] KEIO UNIV,SCH MED,DEPT DERMATOL,SHINJUKU KU,TOKYO,JAPAN

[2] URAWA MUNICIPAL HOSP,DEPT DERMATOL,URAWA,SAITAMA,JAPAN

[3] TACHIKAWA KYOSAI HOSP,TACHIKAWA,TOKYO,JAPAN

[4] KAWASAKI MUNICIPAL HOSP,KAWASAKI,KANAGAWA,JAPAN

来源：

DERMATOLOGY | 1994年 / 189卷 / 02期

关键词：

CUTANEOUS AMYLOIDOSIS; POLYCLONAL IMMUNOGLOBULINS; SJOGRENS SYNDROME;

D O I：

10.1159/000246814

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare disease, and its pathogenesis of amyloid deposition is still unknown. Objective: The purpose of this study was to know the origin of amyloid in PLCNA. Methods: Water-soluble amyloid fibrils were isolated from the skin and resolved on SDS-PAGE, then subjected to immunoblot analysis. Results: The major amyloid fibril protein was a 29-kD peptide which reacted with both anti-lambda- and anti-kappa-light-chain antibodies. Conclusion: Amyloids in this particular case of PLCNA are derived from the polyclonal immunoglobulin light chain and some cases of PLCNA could be reactive diseases rather than neoplastic ones.

引用

页码：125 / 128

页数：4

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