CHARACTERIZATION OF THE AMYLOID FIBRIL FROM PRIMARY LOCALIZED CUTANEOUS NODULAR AMYLOIDOSIS ASSOCIATED WITH SJOGRENS-SYNDROME

被引：25
|
作者：
INAZUMI, T
HAKUNO, M
YAMADA, H
TANAKA, M
NAKA, W
TAJIMA, S
HARADA, T
NISHIKAWA, T
机构：
[1] KEIO UNIV,SCH MED,DEPT DERMATOL,SHINJUKU KU,TOKYO,JAPAN
[2] URAWA MUNICIPAL HOSP,DEPT DERMATOL,URAWA,SAITAMA,JAPAN
[3] TACHIKAWA KYOSAI HOSP,TACHIKAWA,TOKYO,JAPAN
[4] KAWASAKI MUNICIPAL HOSP,KAWASAKI,KANAGAWA,JAPAN
来源：
DERMATOLOGY | 1994年 / 189卷 / 02期
关键词：
CUTANEOUS AMYLOIDOSIS; POLYCLONAL IMMUNOGLOBULINS; SJOGRENS SYNDROME;
D O I：
10.1159/000246814
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background: Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare disease, and its pathogenesis of amyloid deposition is still unknown. Objective: The purpose of this study was to know the origin of amyloid in PLCNA. Methods: Water-soluble amyloid fibrils were isolated from the skin and resolved on SDS-PAGE, then subjected to immunoblot analysis. Results: The major amyloid fibril protein was a 29-kD peptide which reacted with both anti-lambda- and anti-kappa-light-chain antibodies. Conclusion: Amyloids in this particular case of PLCNA are derived from the polyclonal immunoglobulin light chain and some cases of PLCNA could be reactive diseases rather than neoplastic ones.
引用
收藏
页码：125 / 128
页数：4
相关论文
共 50 条
  • [1] SUBCUTANEOUS NODULAR AMYLOIDOSIS IN SJOGRENS-SYNDROME
    PABLOS, JL
    COGOLLUDO, V
    PINEDO, F
    CARREIRA, PE
    [J]. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 1993, 22 (05) : 250 - 251
  • [2] Primary localized cutaneous nodular amyloidosis: A cutaneous manifestation of Sjogren syndrome
    Vachiramon, Vasanop
    Kovarik, Carrie
    Vivino, Frederick
    Werth, Victoria
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2009, 60 (03) : AB66 - AB66
  • [3] Nodular primary localized cutaneous amyloidosis
    Santos-Juanes, J
    Galache, C
    Curto, JR
    Astudillo, A
    del Río, JS
    [J]. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2004, 18 (02) : 224 - 226
  • [4] Nodular localized primary cutaneous amyloidosis
    Katz, KA
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2002, 147 (02) : 400 - 400
  • [5] NODULAR LOCALIZED PRIMARY CUTANEOUS AMYLOIDOSIS
    CLEMENT, MI
    HONAVAR, M
    SALISBURY, J
    NEILL, S
    [J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1987, 12 (06) : 460 - 462
  • [6] NODULAR PRIMARY LOCALIZED CUTANEOUS AMYLOIDOSIS
    CHAPEL, TA
    BIRMINGHAM, DJ
    MALINOWSKI, YE
    [J]. ARCHIVES OF DERMATOLOGY, 1977, 113 (09) : 1248 - 1250
  • [7] Primary localized cutaneous nodular amyloidosis
    Roberts, Amanda
    Neal, Danielle
    Brown, Patrick
    Dalton, Scott
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2018, 79 (03) : AB229 - AB229
  • [8] Nodular localized primary cutaneous amyloidosis and primary Sjogren's syndrome
    Davies, K.
    Collins, A.
    Charlton, F. G.
    Ng, W-F
    [J]. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2020, 49 (02) : 159 - 160
  • [9] Primary Sjogren Syndrome Manifested as Localized Cutaneous Nodular Amyloidosis
    Wey, Shiow-Jiuan
    Chen, Yi-Ming
    Lai, Po-Ju
    Chen, Der-Yuan
    [J]. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2011, 17 (07) : 368 - 370
  • [10] NODULAR PRIMARY CUTANEOUS AMYLOIDOSIS - ISOLATION AND CHARACTERIZATION OF AMYLOID FIBRILS
    KITAJIMA, Y
    SENO, J
    AOKI, S
    TADA, S
    YAOITA, H
    [J]. ARCHIVES OF DERMATOLOGY, 1986, 122 (12) : 1425 - 1430
12345