SYNTHESIS AND NOOTROPIC ACTIVITY OF 2-OXO-1-PYRROLIDINESULFONIC ACID-DERIVATIVES

被引：0

作者：

CERRI, A ^{[1
]}

FARINA, C ^{[1
]}

PINZA, M ^{[1
]}

BANFI, S ^{[1
]}

机构：

[1] IST SCI FIS,RIC BIOMED LAB,I-20090 TREZZANO,ITALY

来源：

FARMACO | 1991年 / 46卷 / 7-8期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The synthesis of a series of 2-oxo-1-pyrrolidinesulfonic acid derivatives, as potential nootropic agents, is reported. Such compounds were designed to have chemical and physico-chemical properties intermediate between 2-oxo-1-pyrrolidineacetamides (e.g. oxiracetam) and 1-acyl-2-pyrrolidinones (e.g. aniracetam). The ability of these compounds to counteract the ECS-induced amnesia in mice was assessed in a one trial, step through, passive avoidance paradigm. Whilst oxiracetam and aniracetam confirmed their antiamnestic action, none of the title compounds showed a statistically significant activity.

引用

页码：959 / 966

页数：8

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