ISOLATION OF A FAMILY OF DROSOPHILA POU DOMAIN GENES EXPRESSED IN EARLY DEVELOPMENT

被引：80

作者：

BILLIN, AN ^{[1
]}

COCKERILL, KA ^{[1
]}

POOLE, SJ ^{[1
]}

机构：

[1] UNIV CALIF SANTA BARBARA, DEPT BIOL SCI, SANTA BARBARA, CA 93106 USA

来源：

MECHANISMS OF DEVELOPMENT | 1991年 / 34卷 / 2-3期

基金：

美国国家科学基金会;

关键词：

DROSOPHILA; DEVELOPMENT; POU DOMAIN; SEGMENTATION; HOMEOBOX;

D O I：

10.1016/0925-4773(91)90045-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The POU domain is a approximately 140 amino acid domain shared by several mammalian transcriptional activators. We have isolated genomic and cDNA clones from three Drosophila POU domain genes, designated pdm-1, pdm-2, and Cf1a. All three genes encode a conserved POU-specific domain and a POU homeo domain but are otherwise divergent. By Northern analysis, all three of the genes are expressed in early embryos; the pdm-1 and Cf1a genes are also expressed at lower levels throughout development. The spatial expression patterns of the pdm-2 and Cf1a genes show that they probably play multiple roles during development: an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.

引用

页码：75 / 84

页数：10

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