NICOTINATE ESTERS - THEIR BINDING TO AND HYDROLYSIS BY HUMAN SERUM-ALBUMIN

被引：11

作者：

STEINER, A ^{[1
]}

MAYER, JM ^{[1
]}

TESTA, B ^{[1
]}

机构：

[1] UNIV LAUSANNE,SCH PHARM,CH-1015 LAUSANNE,SWITZERLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 09期

关键词：

D O I：

10.1111/j.2042-7158.1992.tb05512.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nicotinate esters were studied for their binding to, and hydrolysis by, human serum albumin. Some esters (ethyl, isopropyl, t-butyl, cyclohexyl, benzyl) were bound but not hydrolysed, while others (2-chloroethyl, 2-butoxyethyl) displayed the opposite behaviour: 1-carbamoylethyl ester was neither bound nor readily hydrolysed. Only p-methoxyphenyl nicotinate was both a ligand and a substrate, and its rate constants of binding and hydrolysis were calculated in a stepwise procedure using a kinetic model.

引用

页码：745 / 749

页数：5

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