NICOTINATE ESTERS - THEIR BINDING TO AND HYDROLYSIS BY HUMAN SERUM-ALBUMIN

被引：11
|
作者：
STEINER, A [1 ]
MAYER, JM [1 ]
TESTA, B [1 ]
机构：
[1] UNIV LAUSANNE,SCH PHARM,CH-1015 LAUSANNE,SWITZERLAND
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 09期
关键词：
D O I：
10.1111/j.2042-7158.1992.tb05512.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nicotinate esters were studied for their binding to, and hydrolysis by, human serum albumin. Some esters (ethyl, isopropyl, t-butyl, cyclohexyl, benzyl) were bound but not hydrolysed, while others (2-chloroethyl, 2-butoxyethyl) displayed the opposite behaviour: 1-carbamoylethyl ester was neither bound nor readily hydrolysed. Only p-methoxyphenyl nicotinate was both a ligand and a substrate, and its rate constants of binding and hydrolysis were calculated in a stepwise procedure using a kinetic model.
引用
收藏
页码：745 / 749
页数：5
相关论文
共 50 条
  • [1] BINDING OF DIPHENYLHYDANTOIN BY HUMAN SERUM-ALBUMIN
    BROWNE, RK
    ZAROSLIN.JF
    OESTER, TY
    [J]. FEDERATION PROCEEDINGS, 1972, 31 (02) : A537 - &
  • [2] INFLUENCE OF STEROID BINDING ON TRYPTIC HYDROLYSIS OF SERUM-ALBUMIN
    RYAN, MT
    [J]. BIOCHEMISTRY, 1973, 12 (12) : 2221 - 2230
  • [3] BINDING OF CATECHOLAMINES TO HUMAN SERUM-ALBUMIN
    DANON, A
    SAPIRA, JD
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1972, 182 (02): : 295 - &
  • [4] THE BINDING OF PHYSOSTIGMINE TO HUMAN SERUM-ALBUMIN
    WHELPTON, R
    HURST, PR
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1990, 42 (11) : 804 - 805
  • [5] BINDING OF PROSTAGLANDIN TO HUMAN SERUM-ALBUMIN
    UNGER, WG
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1972, 24 (06) : 470 - &
  • [6] STEREOSELECTIVE BINDING OF ETODOLAC TO HUMAN SERUM-ALBUMIN
    MULLER, N
    LAPICQUE, F
    MONOT, C
    PAYAN, E
    DROPSY, R
    NETTER, P
    [J]. CHIRALITY, 1992, 4 (04) : 240 - 246
  • [7] NATURE OF THE HABA BINDING TO HUMAN SERUM-ALBUMIN
    TARNOKY, AL
    NICHOLSON, BH
    SAVVA, D
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1991, 19 (03) : S333 - S333
  • [8] BINDING OF ZINC AND CADMIUM TO HUMAN SERUM-ALBUMIN
    TRISAK, ST
    DOUMGDEE, P
    RODE, BM
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1990, 22 (09): : 977 - 981
  • [9] Binding and hydrolysis of soman by human serum albumin
    Li, Bin
    Nachon, Florian
    Froment, Marie-Therese
    Verdier, Laurent
    Debouzy, Jean-Claude
    Brasme, Bernardo
    Gillon, Emilie
    Schopfer, Lawrence M.
    Lockridge, Oksana
    Masson, Patrick
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2008, 21 (02) : 421 - 431
  • [10] MODULATION OF IGG BINDING TO SILICONE BY HUMAN SERUM-ALBUMIN
    GOLDBLUM, RM
    PYRON, D
    SHENOY, M
    [J]. FASEB JOURNAL, 1995, 9 (04): : A1029 - A1029
12345