GOLD INDUCED NEPHROPATHY IN RHEUMATOID-ARTHRITIS AND HLA CLASS-II GENES

被引：13
|
作者：
SAKKAS, LI
CHIKANZA, IC
VAUGHAN, RW
WELSH, KI
PANAYI, GS
机构：
[1] UNITED MED & DENT SCH,GUYS & ST THOMAS HOSP,DIV MED,MOLEC IMMUNOGENET UNIT,LONDON SE1,ENGLAND
[2] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,DIV MED,TISSUE TYPING UNIT,LONDON SE1,ENGLAND
[3] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,DIV MED,RHEUMATOL UNIT,LONDON SE1,ENGLAND
来源：
ANNALS OF THE RHEUMATIC DISEASES | 1993年 / 52卷 / 04期
关键词：
D O I：
10.1136/ard.52.4.300
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives-To elucidate the role of HLA-DRB, -DQA, and -DQB genes in patients with rheumatoid arthritis (RA) who developed gold induced nephropathy. Methods-Southern blot analysis of HLA-DRB, -DQA, and -DQB genes was performed on DNA from 27 patients with RA with gold induced nephropathy, 37 patients with RA who were treated with gold but did not develop nephropathy, and 122 ethnically matched normal subjects. Results-The 4-7 kb DQA1/Taq I band associated with DQA1*0501 and DR3 and DR5 was found in 16 (59%) patients with gold induced nephropathy compared with five (14%) patients without gold induced nephropathy. Conclusion-It is concluded that HLA-DQA region genes may be an important susceptibility factor for the development of gold induced nephropathy in patients with RA.
引用
收藏
页码：300 / 301
页数：2
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