EFFECTS OF HONOKIOL AND MAGNOLOL ON ACETYLCHOLINE-RELEASE FROM RAT HIPPOCAMPAL SLICES

被引：13
|
作者：
TSAI, TH
WESTLY, J
LEE, TF
CHEN, CF
WANG, LCH
机构：
[1] UNIV ALBERTA,DEPT BIOL SCI,EDMONTON,AB T6G 2E9,CANADA
[2] NATL YANG MING MED COLL,INST PHARMACOL,TAIPEI 112,TAIWAN
来源：
PLANTA MEDICA | 1995年 / 61卷 / 05期
关键词：
D O I：
10.1055/s-2006-958142
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
To study the possible mechanism through which honokiol and magnolol elicit their central depressant effects, we examined the influence of these two phenolic compounds on 25 mM K+-stimulated release of [H-3]acetylcholine (ACh) from the rat's hippocampal slices. Honokiol, but not magnolol, elicited a concentration-dependent enhancement of K+-evoked ACh release. Addition of either tetrodotoxin, pilocarpine, or methoctramine had no effect on honokiol-enhanced ACh release. These results suggest that honokiol enhanced K+-evoked ACh release directly on hippocampal cholinergic terminals via receptors other than the M(2) cholinergic subtypes.
引用
收藏
页码：477 / 479
页数：3
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