PHORBOL ESTER INDUCES PHOSPHORYLATION AND DOWN-REGULATION OF CONNEXIN-43 IN WB-CELLS

被引：128

作者：

OH, SY ^{[1
]}

GRUPEN, CG ^{[1
]}

MURRAY, AW ^{[1
]}

机构：

[1] FLINDERS UNIV,SCH BIOL SCI,GPO BOX 2100,ADELAIDE,SA 5001,AUSTRALIA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1094卷 / 02期

关键词：

PHORBOL ESTER; CONNEXIN-43; PHOSPHORYLATION;

D O I：

10.1016/0167-4889(91)90016-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Western blot analysis indicated that WB cells contained multiple proteins of molecular mass 42-47 K which reacted with anti-connexin 43 antibody. Incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) for 5 min caused the inhibition of dye transfer and the appearance of reactive material of 50 K which was abolished by acid phosphatase. Longer term incubation with TPA caused loss of connexin 43 protein.

引用

页码：243 / 245

页数：3

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