IMMUNOHISTOCHEMICAL DEMONSTRATION OF ALPHAB-CRYSTALLIN IN HAMARTOMAS OF TUBEROUS SCLEROSIS

被引：0
|
作者：
IWAKI, T [1 ]
TATEISHI, J [1 ]
机构：
[1] KYUSHU UNIV,FAC MED,INST NEUROL,DEPT NEUROPATHOL,FUKUOKA 812,JAPAN
来源：
AMERICAN JOURNAL OF PATHOLOGY | 1991年 / 139卷 / 06期
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D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of alpha-B-crystallin. Positive immunoreactions were detected in the harmartomas of various organs. Abnormal expression of alpha-B-crystallin in the hamartomas in conjunction with the alpha-B-crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of alpha-B-crystallin gene expression.
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页码：1303 / 1308
页数：6
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